Hermann thoms



men STATES AT'ENT OFFIom HERMANN THOMS, or BERLIN, GERMANY.

SPECIFICATION forming part of Letters, Patent No. 502,504, dated August1,1893.

Application filed November 18, 1892. Serial No. 452.446. (Specimens) vTo whom it may concern:

Be :itk nqyvn that I, UERMAIIN TnoMs, chemlet, a subject of the Emperorof Germany, residing in the city of Berlin, German Empire, have inventedcertain new and useful Improvements in the Production of Para PhenotelCarbamide; and I do hereby declare that the follewingisla full, clear,and exact description of the invention, such as will enableothers'skiilled in the art to which it appertains to make and use thesame.

My previous'researches (published in the Pharm. Ce ntmlhalle,,March 24,1892,) have shown that di-para-phenetylurea nno moom,

nno moom may be readily obtained, in addition to the hydrochlorid ofphenetidin, by causing carbonylchlorid to act on a solution of paraphenetidin in toluene. Since then I have found that this body, whenheated for several hours with common urea.

NIT,

/Nn 1i,(OCJmNiT IICl-MCO :CO

' mic mo o n in equimolecular proportions in a closed vessel, and at atemperature ranging between 150 and 160 centigrade, is easily convertedinto the para phenetol carbamide as indicated by the following equation:

nnc mocn, Na, tnn'z nponi co +00 =2co Instead of the common urea thecarbamide salt of ammonia or commercial ammonium carbonate may beemployed. The reaction takes place in the first case as indicated by thefollowing equation:

nno moenn +rno nnc nponn co :aco

I have found also, that instead of the dipa-raphenetylureaparaphenetidin or the hydrochlorid of para-phenetidin maybe employed,the latter being either treated in a closed vessel with common urea, orthe carbamide salt of ammonia, or with commercial ammonium carbonate ata temperature of 160 centigrade; or an aqueous solution of thehydroclilorid of theparaphenetidin (three molecules) and common urea(two molecules) being heated and kept at the boiling point for aconsiderable time, the reaction being indicatedby the followingequation;

summoem,

+anmc1.

nnont oe n,

Having thus described my invention, what I. claim as new therein, anddesire to secure by Letters Patent, is-

1. The process of obtaining paraphcnctol .carbamide, by the reaction ofa para salt of phenetidin. on a substance such as common urea in aboutthe proportions set forth.

2. The process of obtaining para-phenetolcarbamido, which consists inboiliugan aqueous solution of para-phenetidin-hydrochlorid with commonurea in about the proportions set'forth.

IIERMANN TIIOMS.

Witnesses:

FRITZ RINDEL, Ace. FRAHNE.

